Experimental Study on the Effect of Acupuncture on ERM/PI3/Akt Signal Pathway in Rats with Ischemic Stroke

Objective: To observe the effect of acupuncture on expression ERM/PI3K/Akt signaling pathway in brain tissue around infarct focus ischemic stroke model rats. Methods: According to block randomization method, 80 male SD rats were divided into normal group (n = 10), sham operation 24), 23) and 23). The was bred routinely without any intervention. In group, only skin cut find nerves blood vessels stripped sutured. sutured prepare MCAO model. After successfully established, given once a day, needles kept for 30 minutes each time. imitated capture return, treated with 2 consecutive courses, course 5 days, two courses rested days. that, Western blot used detect ERM, changes concentration PI3K Akt proteins. Results: Compared levels PI3K, proteins reduced. significantly down-regulated. protein up-regulated difference statistically significant (P < 0.05). Conclusion: Acupuncture can up-regulate proteins, its mechanism may be related transduction cells.